Date: Dec 1, 2025
Category: Health & Technology
Recent studies highlight the crucial role of metabolic reprogramming in the tumor microenvironment of pancreatic ductal adenocarcinoma (PDAC). Notably, high lactate dehydrogenase A (LDHA) activity has been linked to increased expression of urokinase-type plasminogen activator receptor (uPAR) in monocytic myeloid-derived suppressor cells (M-MDSCs). This upregulation of uPAR in M-MDSCs under elevated LDHA activity fosters an immunosuppressive environment, promoting tumor progression and resistance to therapy. For instance, Siegel et al. (2023) provide comprehensive cancer statistics, underscoring the aggressive nature of PDAC and the urgent need for novel therapeutic strategies. Moletta et al. further discuss the challenges of surgical intervention in recurrent pancreatic cancer, emphasizing the importance of understanding tumor biology for improved outcomes. Emerging evidence suggests that targeting metabolic pathways, such as LDHA, could modulate the immunosuppressive functions of M-MDSCs by reducing uPAR expression. This approach holds promise for enhancing anti-tumor immunity and improving the efficacy of existing treatments in PDAC patients. Ongoing research continues to unravel the complex interplay between tumor metabolism and immune evasion, paving the way for innovative therapeutic interventions. Read the source »
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